The prototypical mad scientists and arch-enemies of the most powerful caped crusaders in golden age comics were distorted versions of each other. In more ways than one, actually. Alexie Luthor, who shortly after his debut lost his crop of red hair and turned bald (a later retcon established that all 1940's tales of Luthor had him still possessing a scalp full of locks), was Superman's most enduring adversary. So to was Doctor Thaddeus Bogus Sivana for his foe, the "Big Red Cheese" known as Captain Marvel. Finishing our triad of terror was the silver age Lex Luthor, bad and bald right from the beginning of his criminal career.
All three possessed stunningly sinister minds allowing them to develop advanced technology to attemp controlling the world, or at least their portion of their planet i.e Metropolis of Earth-One and Earth-Two or Fawcett City of Earth-S. Each spawned children, although Lex's infant perished on his adopted world Lexor while Sivana's four children grew into adults on Venus. Each employed means of copying their greatest enemy's powers if only briefly, and they at times worked alongside fellow felons who had also incurred the wrath of the Men of Steel and Mightiest Mortal. Nevertheless, their most prominent aptitude wasn't their genius, nor their ego, but their persistence even in the face of defeat after defeat throughout the decades to come.