Two such were Janet Klyburn and Gerta Von Gunther. Each lass were prominent red headed scientists, who at times found themselves abducted by the forces of evil, and were tied to artificial superhumans who challenged the might and muscle of Superman and Wonder Woman, respectively.
Janet was the director and lead scientist of S.T.A.R. Laboratories in the Metropolis of Earth-One. Gerta gained from her mother, the formerly evil Paula Von Gunther, an outstanding intellectual capacity herself. While Gerta used this ability to enlarge and mutate animal life forms such as the Bughumans, Janet found the key compound needed to eradicate the non-living duplicates spawned from the original Solomon Grundy.