Perpetual pest of protagonists, Doctor Arthur Light, abandoned his solo pursuits at defeating the combined Justice League of America and individual members, to recruit a team of super-villains. Aiming his sights lower, defeating the New Teen Titans, he felt he had the right mixture to accomplish this and more. Recruiting the dwarf Gizmo (aka Mikron O'Jeneus), a genius developing multiple weapons; the brother and sister team of super-strong Mammoth and the matter-transmute maiden of Shimmer; (aka Baran and Selinda Flinders) and the mental mastermind Psimon (aka Dr. Simon Jones), the Fearsome Five were born. When this team betrayed Light and recruited eastern femme fatale Jinx and former Superman foe Neutron, and still met bitter defeat, this time by both the Titans and the Outsiders). Finally, Psimon was killed by Brainiac and the Doctor retired as did his teammates.
There was a corresponding team on Earth-Two known as the Five Fingers of the Hand that battled the Seven Soldiers of Victory, consisting of foes of each of the members. Consisting of Red Dragon, Professor Merlin, Needle, Big Caesar, Dummy and the Hand himself as their leader. Each would recur as enemies of the Soldiers, but only joined forces together once.