Alexander Tuttle was the son of a wealthy business man, who sought to pursue a scientific career. However, Alexander's domineering father demanded that his son follow him in his construction business. Over the years, this mental flogging led to the younger Tuttle becoming insane and developing a power glove that allowed him to break apart atomic structures. As the Crumbler, he battled Green Lantern, Green Arrow and Black Canary twice then later allied himself with Professor Ojo to once more face the trio of heroes. Eventually, Tuttle was brought to justice and never reappeared as he remained in Arkham Asylum.
The Hand was a crime boss of the 1940's that though he had an incurable condition which had misdiagnosed, and banded together several criminals to form his Five Fingers. Although they were defeated by Earth-Two's Law's Legionnaires and this cost him his right hand, literally, he replaced it with an iron hand powered by nebula energy of which he renamed himself. This appendage gave him tremendous power to destroy objects and control his nebula hand which encircled the world. The combined might of the Legion with the League and Society of Justice unseated his schemes.