Mister Who of Earth-Two was a crippled scientist who discovered the Z-Solution, a formula developed from the adaptive ability of animals. Having been the object of scorn and derision by others all his life, he turned his animus against his fellow man to become a crime boss. From the solution, he gained the ability to adapt his size to become a giant or a midget, later his shape to become other people or animals, and other attributes when needed.
Despite reports to the contrary, Anton Arcane didn't perish from his fall, as his body was retrieved by the Un-Men. They transformed their master into a hulking monstrosity, Despite now having superhuman strength and comparable physique, Anton was still no match for Swamp Thing and this time appeared to be disassembled.
As a shape-changing supervillain, Mister Who came into conflict time and again with Doctor Fate, trying various schemes to amass vast ill gotten gains and power. Yet each time, Who met defeat despite his tremendous powers and brilliant mind along with several nefarious schemes. However, his infamy came to the attention of the malevolent Mister Mind, arriving on Earth-Two after Who’s third appearance left him imprison. Soon, this bearded bad guy would find himself surrounded by fellow freaks focused on felony.
Yet again, Arcane returned, this time transformed into a human-insect hybrid. The results were the same in the end, as a third encounter versus his arch-enemy this time seemingly left him finally dead.
Mister Who joined Mister Mind's Monster Society of Evil, and found that the assembled All-Star Squadron was too powerful for he and his cronies as they were quickly vanquished while the Crisis on Infinite Earths was transpiring. Who would reappear once more following this tale and again meet defeat versus Fate. While all three of his solo schemes involved petty larceny, the science behind them had untapped potential squandered by the greed and malice of its creator.
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