Along the way, other super villains such as Garguax and General Immortus joined the Brotherhood for a time, on each occasion battling and being vanquished by their opposite number, the Doom Patrol.
In a parallel reality decades prior on Earth-Two, the illicit insect known as Mister Mind recruited several adversaries of the Justice Society of America to become his wicked take on that team known as the Monster Society of Evil. Included in their membership was the giant genius known as Mister Who, who could alter his form at will, and the clever criminal known as the Dummy. This Dummy was a wooden automaton created by the original Dummy, who was a foe of Earth-Two's Vigilante, and had a copy of his master's brain.
Other recruits in the Monster Society were Ramulus and Nyola as well as the willful stone brute known as Oom, which made this evil assemblage a true threat to the All-Star Squadron.
After a number of encounters, the Brotherhood fractured as Rogue rebelled against both the Brotherhood's Brain who was her master and the Patrol's Chief whom she loved, seemingly destroying both groups. The Monster Society had fractured leadership wherein its first leader Mister Mind left that Earth for another, then its second leader Oom was destroyed. While Brain and Dummy, Mallah and Mind... with his Oom body compensating for Monsieur's simian might, and Rogue and Who were counterparts... the Brotherhood's Garguax and Immortus had counterparts in the similar green skinned Jaxo and long-lived Khalis. And the dopplegangers to the Society's Ramulus and Nyola was the Floronic Man and Chak.
Back on Earth-One, the Brain assembled a second team of villains from around the world to compose his new Brotherhood of Evil, this time battling the New Teen Titans and their ally Robotman. Meanwhile, the original Psycho-Pirate enlisted fellow cellmate Roger Hayden to become his protegee in foul play on Earth-Two with Hayden dueling with Hourman and Doctor Fate.
As a result, two teams of a sort were formed to torment the heroes of their worlds. First, there was the mentally manipulating Mango the Mighty and Houngan aka Jean Louis-Droo who used science to control men. Phobia (Angela Hawkins) and Psycho-Pirate II both used their abilities to effect other humans' emotions. This pair also worked with dimensional traveling Warp and Mayoor, which cause their foes to phase out of reality. Pirate later solicited the services of former crime boss Gat Benson, transformed by green plasma into a gigantic beast much like that of the Brotherhood's Plasmus, who used to be Otto Von Furth until his physiology had been altered due to exposure to radioactive radium.
While the Brotherhood of Evil invaded the African country of Zandia and later resurfaced in America, never finding success in the schemes of their leader. Psycho-Pirate struck off on his own after his previous allies Wotan, Mayoor and Benson had failed him, controlling a team of Justice Society members Green Lantern, Flash and Batman until the trio were defeated as was their puppet-master by the rest of the team. The Pirate then allied himself with the Secret Society of Super-Villains until the Crisis when he became the Anti-Monitors right-hand henchmen for a brief time.