These scheming terrifying triads came to the attention of the Doom Patrol as well as the All-Star Squadron. But what was the secret behind these villains?
Turns out the Brain was a former French scientist whose body perished but his brain was preserved thanks to the timely operation of Mallah, a mentally augmented gorilla that had served him for years prior to the death of his body, and formed Earth-One's Brotherhood of Evil to do his bidding. While the counterpart as this evil organization was Mister Mind's Monster Society of Evil on Earth-Two, As for the Monster and his twin brother Jason, the pair each took turns controlling his body, with Jason being the dominant persona until evil impulses caused the mind of his twin who had never developed an individual body asserted control, transforming Roger's form into the Monster that like Mallah had both massive strength and seemingly inhuman features.
While the Brain recruited various criminals to form his Brotherhood of Evil, all freaks like himself and his ape assistant, Mister Mind sought out various adversaries of the Justice Society. French actress Laura DeMille was brainwashed and then operated on by the Brain into becoming the Madame Rogue. Shortly therafter, the Brain gave DeMille the ability to alter her features as well as elasticize her body. She would ultimately aid the Doom Patrol as she fell in love with its leader Niles Caulder, then betray both the Patrol and the Brotherhood. After Niles and the Patrols death, she attempted to conquer an African country and finally met permanent defeat when she perished while battling the New Teen Titans, Robotman and a new Brotherhood.
DeVille's counterpart on Earth-Two was a thespian like herself only of the opposite gender and working for the opposite side of the law in Richard Stanton aka Madame Fatal. As Fatal, Stanton sought to track down the man who kidnapped his daughter, and began a career in the early 1940's pursuing various criminals fighting for the cause of justice. From one account by the supervillain the Shade, Richard finally located them both and retired his alter ego as Madame Fatal.
Eventually both the Brotherhood and Society fragmented with the Brain and Mallah forming a new incarnation of their team with four powerful pawns, while the Monster was later employed by Per Degaton into a new assemblage of time tossed tyrants in the early 1940's who battled the All-Star Squadron during their initial formation.