Beginning in the 1970's, Batman found himself encountering far stranger foes and even some freaky friends then he ever had met before. First among these was zoologist Kirk Langstrom, who injected himself with an experimental bat gland extract in order to replicate through genetics the abilities of a bat, partially as a tribute to Earth-One's Dark Knight. Instead, Kirk as Man-Bat became mad when his appearance and demeanor transformed him into a bestial version of his hero. Eventually, he sought out his fiancee Francine Lee and convinced her to become his mate, the She-Bat. The pair was eventually cured by the Batman after several confrontations, and for a time Man-Bat was a freelance vigilante for hire working alongside Jason Bard.
Not long thereafter, Batman encountered Anthony Lupus who was an Olympic Decathlon champion plagued with severe headaches, which criminal scientist Professor Milo cured by artificially transforming Lupus into a psuedo-werewolf. Sending Lupus on a mission to kill his old foe the Batman, he instead insured his defeat at the hands of the Caped Crusader while Lupus lived in exile in Alaska. Later, Batman would have a rematch with Lupus, convincing him to return with him to Gotham City to help him cure his sister from a deadly affliction. He was never seen thereafter.
Finally, Batman encountered Swamp Thing who was a sentient vegetation mutant with the memories of a dead scientist, and it was this creature that encountered the Patchwork Man who was a mad scientist's deformed brother. Mutated into appearing to be a man-monster, the Patchwork Man eventually assisted his brother's foe Swamp Thing and then returned years later only to meet a tragic end.
On Earth-Two. the United States secret laboratory known as Project M (for Monster) recruited top scientists to develop superhumans such as Miss America, automatons in the image of Robert Crane's Robotman known as the G.I. Robots, and severely injured soldiers remade into the Creature Commandos.
These Commandos consisted of Sgt Vincent Velcro, Private Elliot Taylor, Warren Griffith, Doctor Myrra Rhoades. This team operated mostly in Europe during World War II, created in late 1942 and thus not affiliated with fellow superhumans in the All-Star Squadron. We know that the Commandos were of Earth-Two due to the connection of Project M because of Miss America's creation as well as the part-creator of the G.I. Robots, Robotman's colleague Charles Grayson. This quirky quintet would eventually be exiled into space at the end of war accidentally, as their rocket transport was suppose to send them into Berlin to confront Hitler and the last of his regime to finally and decisively end the war for good.
- Velcro averted imprisonment for decades by being transformed into a man who could transform into a bat much like Man-Bat.
- Taylor was himself known as Patchwork as just as him namesake a universe away he was now a deformed man-monster.
- Griffith was transformed by a similar procedure which Lupus had undergone into a wolf-like man.
- Finally, Rhoades became a serpentine woman mutated by experimental chemicals she had been doused with, although her counterpart Lee was herself a different time of beast woman yet both were.
- The leader of the Commandos, Lt. Matthew Shrieve, was the most monstrous of all of them due to his personality which was different from former Marine Jason Bard who turned his wartime career into the means to become a better person alongside Man-Bat and his frequent ally Batgirl.