Doctor Destiny aka John Dee was originally a scientist devising anti-gravity discs and will-deadening devices, which he employed versus the Justice League. When his elaborate scheme impersonating Green Lantern had failed, the Doctor employed his greatest creation in the Materioptikon. This mechanism allowed him to materialize the dreams of his opponents. Teaming up with various foes of the League on more than one occasion, he attempts to mentally manipulate his opponents into defeat. He failed each time, even when creating a replica of the heroic team.
After a series of confrontations, the League placed mental blocks in place so that Dee could no longer dream, and thereby activate his virtual Materioptikon stored within his mind. This caused his body to wither and resemble a skeletal husk. At this point, Destiny adopted a costume much like that of other supervillains.
Doctor Elba aka Professor Alba was the inventor of an insanity formula known as Solution K, with which he would inject this into the bloodstreams of key witnesses of crime to cause madness. Several members of the Justice Society dealt with the after effects of this formula, and were assisted by non-member Doctor Mid-Nite in determining the root cause and the culprit behind this crime wave.
Elba had himself been mentally manipulated by Henry King aka Brain Wave from behind the scenes, and after Able "met his doom" when accidentally injecting himself with Solution K. Brain Wave decided to become personally involved in the heroes' defeat, even creating a fake Society, and later teamed up with their foes as the Injustice Society.
A month after escaping the Society, in November of 1941, the now insane Elba assumed the identity of Mister Ghool. Using Solution K to simulate death and again mentally manipulate others to do his bidding. He repeatedly faced future Justice Society member Star-Spangled Kid and the Kid’s partner Stripesy, who defeated him on at least two separate occasions.
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