Batgirl and Huntress faced more traditional but still odd opponents in Copperhead and Boa. Copperhead uses his speciality designed slithered outfit on a crime spree in Gotham City on Earth-One, which led the Batgirl along with Batman and Wonder Woman bringing him to justice. Boa led his gang of human serpents in controlling rackets within the Gotham City of Earth-Two. Nearly suffocated by Boa's pet Roxanne, the aspiring hero Blackwing saved the life of the Huntress, and she promptly defeated Boa and his henchmen. .
Medusa aka Dr. Myrna Rhodes was a physician treating the Creature Commandos, when some experimental gases transformed her hair into living serpentine like entities. As the Earth-Two counterpart of Lady Viper, she nevertheless was a heroine rather than a femme fatale. As for her fellow Commandos: Sgt. Vincent Velcro's Earth-One twin was Andrew Bennett, Warren Griffith's twin there was Anthony Lupus, Pvt. Elliot Taylor's twin there was Gregori Arcane, and their leader Lt. Matthew Shrieve's twin there was government agent Matthew Cable... who stalked Swamp Thing. Each of these individuals had interactions with Earth-One's Batman, while the Commandos' activities in Europe during World War II prevented them from meeting Earth-Two's Batman or his fellow All-Star allies.